Li, female, 32 years old, civil servant, work is relatively easy. Six months ago there was no reason to appear depressed, less talk, think work is meaningless, less interaction with colleagues, but basically can adhere to the normal work and life. 1 month ago in the work appeared emotional, loud crying, very fearful, feel very painful and uncomfortable, and even nonsense speech, mental trance, rushed to the hospital to sedative disposal. Later, she returned to a depressed mood state, with a tendency to worsen, and is now unable to go to work normally. The typical manifestations of depression are depressed mood, slowed thinking, reduced volitional behavior, the patient feels unhappy, even negative and anorexic, struggles to consider problems, the mind has become “stupid”, unwilling to do anything, and little interest; self-evaluation is too low, no confidence in the future, no energy, no meaningful life, etc.. There are also physical symptoms such as insomnia, headache, chest tightness, poor appetite and loss of weight. Typical depression is generally not difficult to identify, however, some atypical depressive episodes are often seen clinically and need our attention, such as some depression with physical symptoms as the main symptom, while others are dominated by fatigue, lethargy and other “debilitating” symptoms; there are also some depression “alternative” episodes, manifested as “alternative” episodes. There are also some depressive “alternative” episodes, which are characterized by “agitated” symptoms, such as a patient’s feeling of distress, or emotional outbursts similar to Li’s, such as agitation, crying and laughing, painful tears, or confusion, babbling and fear. These episodes can easily be misdiagnosed as “dysthymia”. The treatment of depression is not difficult, but medication must be combined with psychotherapy, and scientific and standardized principles must be followed. Medication has to be adjusted according to the changes in the condition, and the dosage and course of treatment should be sufficient. Psychotherapy is a slow, long-term process that requires face-to-face communication with a psychiatrist to develop a plan.