Osteomalacia is an autosomal dominant disorder that is very rare, with data showing an incidence of less than 1 in 10 million. The disease is characterized by sclerotic bone lesions most often involving the hands, feet, pelvis, and ends of long bones, and patients may have no clinical symptoms, often being detected incidentally by imaging. Osteomalacia often does not involve bone destruction, the lesions are symmetrically distributed, and the site of predilection is different from that of metastatic disease, which is commonly found in the vertebrae, ribs, and long bones of the backbone. In addition, the bone imaging results of patients with osteomalacia are not abnormal. 1.Prevention There are no effective preventive measures for this disease. 2, other considerations The disease has no signs of bone fragility, no blood chemistry changes, no neurological or endocrine disorders, and no inflammation, necrosis, pathological fractures, etc. Generally, treatment is not necessary and the healing process is good. Some of the patients with the disease in childhood may heal spontaneously when they grow up.