Gallbladder cancer is a common malignant lesion of the biliary tract, with 90% of patients older than 50 years of age and about 3-4 times as many women as men. Epidemiology shows that 70% of patients are associated with gallstones. Gallbladder cancer mostly occurs in the body and bottom of the gallbladder. Its onset is insidious and there are no specific symptoms in the early stage, which makes early diagnosis difficult. Its clinical manifestations are often concealed by the symptoms of other diseases such as gallbladder stones, and it is often in the late stage when it is diagnosed. Some patients are accidentally discovered gallbladder cancer by pathological examination of gallbladder resection specimens. The main clinical symptoms of gallbladder duct include vague pain, distension, discomfort, nausea, vomiting, belching, weakness, lack of appetite, etc. in the middle and upper right abdomen. An enlarged gallbladder can be palpated when the cystic duct is obstructed. When the right upper abdominal mass can be palpated, it is often in advanced stage, often accompanied by abdominal distension, poor appetite, weight loss or wasting, anemia, hepatomegaly, and even jaundice, ascites, and systemic failure. A few tumors penetrate the plasma membrane and cause acute perforation of gallbladder and peritonitis, or chronic penetration to other organs to form internal fistula; it may also cause biliary bleeding, diffuse liver metastasis and liver failure. Surgery is the first choice for gallbladder cancer, and the scope of surgery is determined according to the stage of gallbladder cancer, while chemotherapy or radiation therapy alone is mostly ineffective and can be used as postoperative adjuvant therapy.