Cholangiocarcinoma is usually a malignant tumor originating from the main hepatic duct and extrahepatic bile duct. According to the location, cholangiocarcinoma can be divided into 3 types: cholangiocarcinoma of the hilar region or upper bile duct, cholangiocarcinoma of the middle segment and cholangiocarcinoma of the lower segment. There can be no symptoms in the early stage of the lesion, and with the gradual development of the lesion, the following manifestations can appear clinically. Jaundice: It is the most common symptom, manifested as dark yellow or tea-colored urine, light or white stools, yellow eyes and skin with itchy skin. Jaundice is the result of biliary obstruction, which is mostly progressive and aggravated, and its degree is related to the site and degree of obstruction. Jaundice is deeper in cases of extrahepatic bile duct obstruction and lighter in cases of intrahepatic bile duct branch obstruction. Jaundice is deeper in complete bile duct obstruction and lighter in incomplete bile duct obstruction. Occasionally, inflammation and spasm of the bile ducts, as well as tumor detachment and deviation of the papillary type of tumor, can make the jaundice fluctuate. Abdominal pain: It may present as mild discomfort in the epigastrium after eating, or vague discomfort under the saber, or back pain, or right upper abdominal cramps, which are manifestations of nerve invasion. It can appear before or after jaundice. Fever: Mostly due to cholangitis after bile duct obstruction, manifested as high fever and chills, and the body temperature can quickly reach over 38 degrees. Other: there may be concomitant symptoms such as loss of appetite, aversion to oil, fatigue, weight loss, nausea and vomiting, or non-specific symptoms of cancer. Jaundice is the most important clinical symptom of cholangiocarcinoma, which is mostly progressive and deepening, and its degree is related to the site and degree of obstruction. If the tumor is advanced due to peritoneal invasion, or invasion of large vessels such as portal vein, resulting in portal hypertension, ascites may appear.