The total prostate-specific antigen is usually high and can be seen in prostate cancer, prostate hyperplasia, and also in prostatitis and other diseases. local physical examination and stimulation of surgical operations may also cause the index to be high. 1. prostate cancer, prostate hyperplasia: the total prostate-specific antigen lacks tumor specificity, which means that even if it is not a prostate tumor, a high total prostate-specific antigen may occur. In clinical practice, the ratio of free prostate-specific antigen to total prostate-specific antigen is often further determined to better distinguish between prostate cancer and prostate hyperplasia. If the ratio of free prostate specific antigen and total prostate specific antigen is significantly increased, it is mostly seen in benign prostate hyperplasia, while a decrease in the ratio of free prostate specific antigen and total prostate specific antigen is closely related to prostate cancer. 2. prostatitis: for example, acute prostatitis or recurrent chronic prostatitis, the total prostate specific antigen may be high, which may be several or even tens of times higher, sometimes with symptoms such as chills and fever. 3. local physical examination: for example, rectal examination, prostate massage and other local irritation examinations. The local stimulating examinations such as rectal finger examination, prostate massage, etc. may cause high total prostate-specific antigen, so before checking this index, usually avoid such physical examinations, otherwise the test results will be inaccurate; 4. surgical operations: such as catheterization, urethral stricture expansion, cystoscopy, etc. These operations may cause high total prostate-specific antigen, but the effect is usually slight, only under special conditions, the test value will rise The effect is usually mild, but only under special circumstances can the test be significantly elevated.