AS (ankylosing spondylitis) is often recurrent and is characterized not only by physical pain, but also by psychological disorders, with anxiety and depression being more common. As the disease progresses, the chances of developing psychological problems increase significantly. This is often manifested as: depression, sleep disorders, reduced ability to live and work, decreased sexual interest, loss of interest, fatigue, irritability, and feelings of uselessness. The long-term existence of this psychology will have a negative impact on the physiological and social functions of the patient, resulting in a decrease in immunity and a slowdown in physiological activities. Modern medicine also believes that when a person is in a negative psychological state such as pessimism, pain, depression and fear, it will lead to changes in the human hypothalamus, endocrine system and vegetative nervous system, abnormal hormones and enzymes in body fluids, decrease in endogenous pain-inhibiting substances and increase in pain-causing substances, making the pain longer or more severe. This results in a vicious cycle of: psychology; pain; psychology, neurological weakness and reduced digestive and absorption functions, increased joint pain symptoms, sleep and nutritional balance. Therefore, in addition to the physiological aspects, AS patients should also pay attention to the prevention of various negative psychological factors, so that they can be detected and solved in time.