The occurrence of depression is the result of the combined effect of biological, genetic and social factors. Therefore, the treatment of depression should start from physical, psychological and social support, and adopt the treatment of integrated biological, psychological and social interventions to achieve effective control of the disease, eliminate symptoms and restore social functions, and finally overcome depression. Integrated interventions for depression include medication, psychotherapy, repetitive transcranial magnetic stimulation, electroconvulsive therapy, relapse prevention measures, and social support help. Alterations in biochemicals in specific parts of the human brain, including abnormal metabolism of biochemicals in the central nervous system and neuroendocrine disorders, can give rise to depressive symptoms in humans. In other words, there is a corresponding material basis for the production of depressive mood in humans. According to the alteration of biochemical substances in the brain, human beings have developed a series of drugs for the treatment of depression, which have achieved better efficacy in clinical practice. Drug treatment of depression should follow the following principles: 1. Depression is a common symptom in mental illness, and depressive symptoms can occur in a variety of mental illnesses, just as fever is a symptom that can occur in a variety of diseases in internal medicine, so the diagnosis must be clear, and the principles of medication for different diagnoses are not exactly the same. 2, the application of antidepressants must reach the therapeutic amount, otherwise the treatment effect is not good, and may also delay the disease. 3, because depression is a disease prone to relapse, so in recent years the internationally recognized course of antidepressants is generally divided into three phases, namely, the acute treatment period, the consolidation treatment period, and the maintenance treatment period. Taking the first onset as an example, the duration of the three phases are: 6 to 8 weeks, 4 to 5 months, 6 months to 1 year; if it is a relapse of depression, the duration of medication should be extended. 4, the use of antidepressant drugs should be selected according to the patient’s age, physical condition and possible adverse drug reactions, and also take into account the mechanism of action of drugs, drug interactions and other issues. In the process of treating depression, we should also pay attention to the degree of cooperation of the patient and adhere to the full dose and full course of treatment in order to obtain the best effect of depression treatment. Drugs have a great role in the treatment of depression. About 90% of patients with depressive disorders are effectively treated by antidepressant drugs. After successful treatment of depressive disorder with antidepressants, the percentage of those who continue to stay healthy for more than one and a half years is 70-80%. Therefore, medication is a very important approach in the treatment of depression.