Patients with painful duodenal ulcers should be given a combination of drugs to inhibit gastric acid secretion, protect the gastric mucosa, and anti-H. pylori, as follows: 1. Drugs to inhibit gastric acid secretion: commonly used drugs to inhibit gastric acid secretion include omeprazole, rabeprazole, pantoprazole, esomeprazole, lansoprazole, etc., which reduce the irritation and damage of gastric acid to the wall of the duodenal ulcer by inhibiting gastric acid secretion. 2. 2, protection of gastric mucosa drugs: gastric mucosa protective agents commonly used are aluminum thioglycollate, magnesium aluminum carbonate, bismuth pectin, etc., to protect the duodenal mucosa and reduce the erosive stimulation of gastric acid. 3, anti-Helicobacter pylori treatment: while checking H. pylori, if there is H. pylori infection, give clarithromycin, amoxicillin antibacterial therapy. If the patient has severe pain, to exclude the presence of duodenal spasm or perforation, gastrointestinal disease patients with worsening discomfort symptoms, to immediately consult a doctor, under the guidance of the doctor to adjust the medication, if necessary, supplemented by gastroscopy, to understand the lesion, so as not to delay the disease. Give a light, easily digestible liquid or semi-liquid diet, prohibit cold, spicy, greasy and other stimuli, eat less and more meals, do not overeat, maintain good rest and mood, protect the gastrointestinal mucosa, and promote recovery.