1. Incidentally discovered during physical examination, surgery, autopsy or other examinations, they are called “stationary gallbladder stones” or “asymptomatic gallbladder stones”, about 20-40% of them. However, a lot of clinical data show that long-term gallbladder stones are likely to induce gallbladder cancer, especially in female patients with higher incidence. In fact, this is wrong. Most patients with gallbladder stones in the stable phase or in the stable phase show “stomach discomfort”, “gastritis”, “right shoulder and back discharge pain”. “These patients are not asymptomatic group. 3.Treatment method: At present, the biliary endoscopy technology can adopt the minimally invasive method of “removing the stone and preserving the gallbladder”, so the patient can avoid the pain of gallbladder removal. 4. Timing of surgery: It is best to perform minimally invasive treatment for gallbladder stone extraction during the stable or steady stage. Long-term repeated stone stimulation of the gallbladder, chronic inflammation of the gallbladder, eventually leading to impaired function of the gallbladder, until no function, the end only gallbladder removal.