When you see this title, I believe some readers will be very confused – isn’t the prostate part of the genitourinary system? How can it be related to mental illness? It is necessary to popularize to the readers that many non-psychiatric diseases induce changes in the psychological and mental state of the patients and gradually aggravate into psychiatric symptoms. In this case, we will introduce the psychiatric symptoms caused by prostate diseases. (1) Prostatitis Prostatitis mostly develops in middle-aged and young men, which is the sexually active period of their lives. When the symptoms of prostatitis strike, sexual life is often affected by it. This influence will in turn aggravate sexual dysfunction such as impotence and premature ejaculation, forming a vicious circle. Some patients will have severe pain in the prostate after ejaculation, which may further reduce the patient’s desire to engage in sexual activity. In the long run, some patients with chronic prostatitis will suffer from long-term sexual repression and low self-esteem, leading to depression, anxiety and other mental symptoms. In the past, it was widely believed that sex was not relevant to the elderly and that this factor did not need to be taken into account during the treatment process, but now both doctors and the public are gradually correcting this misconception. (3) Prostate cancer Patients with prostate cancer will experience mental symptoms similar to those of patients with benign prostatic hyperplasia, but because the disease is more serious, and because of the adverse effects of depot treatment, the mental symptoms of patients should not be taken lightly. It is actually unnecessary to carry the burden of thought because of the prostate disease, which then develops into mental symptoms. Patients should be brave enough to face the disease, change bad habits, adhere to regular treatment, and can actively demand psychological comfort and assistance while treating the disease, which can effectively prevent and reduce the occurrence of psychiatric symptoms, thus improving the patient’s self-confidence and the possibility of effective treatment.