The International is now difficult and unresolved. According to foreign guidelines, it is very difficult to achieve disappearance of surface antigen. It is very difficult. the disappearance and negative conversion of HBsAg is very difficult. the negative conversion of HBsAg and hematological conversion is the most difficult and slow. It is done with the quantitative HBsAg test to see if it continues to decline, and it also takes 3 to 5 years to appear. It is slower to produce results. Interferon needs to be observed for 3 to 4 years after stopping the drug, and nucleoside (acid) drugs cannot be stopped yet. Now we can only place the endpoint of treatment at undetectable HBV DNA and normal ALT. This is relatively easy, but reaching this endpoint is not the same as stopping the drug. Our guidelines require undetectable HBV DNA and normal ALT for at least 1.5 years, while foreign countries require 2 to 3 years. But this is not evidence-based medical evidence. It can only be used until this time to stop the drug to try, if the effect is very stable, stop, if the drug is stopped and then relapsed again with the drug. So unlike HBeAg positive patients, generally HBeAg hematology conversion and then continue to use 1 year before stopping the drug. But relapse can also occur. The relapse rate is relatively high in Asia, with Korea reporting a 50% relapse rate. Relatively speaking HBeAg serologic conversion is the endpoint of treatment for HBeAg positive patients who can be discontinued and observed, and close observation and relapse after discontinuation must be taken into account. For HBsAg the endpoint is more difficult and uncertain.