Generally speaking, the more common symptoms of gallbladder cancer are jaundice, abdominal pain, weight loss, loss of appetite, fever, nausea or abdominal swelling and pain. Sometimes, it may be accompanied by other organ metastases such as itchy skin and breathlessness. In fact, when we see jaundice and other symptoms in clinical practice, it is often in the advanced stage of gallbladder cancer. In other words, there are few special symptoms of gallbladder cancer, so it is difficult to pay special attention to it, and it is relatively more difficult to detect it in early stage. Specific symptoms include the following: 1. Discomfort in right upper abdomen with continuous hidden pain or dull pain, which accounts for 84% of the symptoms. Since gallbladder cancer mostly coexists with gallbladder stones and inflammation, the nature of pain is similar to that of stone cholecystitis, which starts with discomfort in right upper abdomen, followed by persistent hidden pain or dull pain, sometimes accompanied by paroxysmal severe pain and radiating to right shoulder. 2, digestive symptoms most of the time (90%) appear indigestion, aversion to greasy, belching, reduced appetite, which is due to the gallbladder renewal function, can not be digested fatty substances. 3.Jaundice often appears in the late stage of the disease, manifested in mucous membrane and skin yellow staining, yellow staining is more serious, accounting for 36.5%, mostly due to cancer tissue invasion of bile ducts, causing malignant obstruction. It is also accompanied by emaciation, weakness and even cachexia, yellow staining of skin and mucous membrane, with untreatable itching of skin. 4. Right upper abdomen or epigastric mass, rapid growth of tumor, obstruction of bile duct, enlargement of gallbladder, obstruction caused by tumor invasion of duodenum, and obstruction symptoms at the same time; in addition, invasion of liver, stomach, pancreas, etc. may also appear corresponding parts of the mass.