Large base weight people to lose weight, control diet and exercise exercise is a safer and more effective method, but weight loss should be moderate and gradual. Excessive, too fast weight loss will cause adverse effects on the body, to adopt a scientific and correct way to lose weight.1, diet: to eat reasonably, planned to gradually reduce the amount of diet, not excessive dieting, so as not to cause the occurrence of hypoglycemia. Advocate less salt, less oil, less sugar diet, such as reducing the intake of rice, bread and other staple foods, eat more fiber-rich coarse grains, fruits and vegetables. Balanced diet with a balanced diet every day in accordance with the customized diet plan; 2. Exercise: people with large base weight are prone to injury when losing weight, the amount and intensity of exercise should be moderate and reasonable, avoiding some exercises that exceed the body’s load capacity, such as jumping rope, climbing mountains, etc., to avoid damage to the joints. It is recommended to carry out exercises such as swimming and aerobic running, which are not obvious for joint damage, and you can do some stretching preparation before exercise to avoid injury. If obesity has affected the patient’s life and health, and the only way to solve the problem is through surgical treatment, we should consider early weight reduction surgery. If the patient is overly obese due to disease, the primary disease causing the obesity should also be actively treated. People with large base weight are prone to diseases of the cardiovascular system and also affect the quality of life. It is necessary to carry out correct and effective weight loss, and moderate weight loss can reduce the risk of developing obesity and its complications, and also improve the health of patients.