Long-term use of cholestatic drugs is not recommended for either symptomatic or asymptomatic gallbladder stones, either before or after cholecystectomy. Many patients take cholestatic drugs because of the misconception that they can dissolve gallbladder stones, prevent stone recurrence, or effectively reduce the rate of acute attacks, and some patients even use them as laxatives. Current research has not yet shown that any drug in the world can effectively dissolve gallbladder stones or prevent stone recurrence, nor has it been reported that any drug can prevent acute cholecystitis attacks. The majority of domestic cholagogic drugs are proprietary Chinese medicine preparations, most of which also have rhubarb components. Current research suggests that taking rhubarb-like substances for more than six months can cause the intestinal mucosa to get nigrosis, that is, the intestinal mucosa turns from normal red to dark black under colonoscopy.