Highly differentiated liposarcoma is a malignant tumor, which is serious compared to benign diseases, and the severity is related to the tumor stage, pathology, treatment effect and patient’s status, etc. Normative treatment is recommended. Highly differentiated liposarcoma is a complex and heterogeneous malignant tumor originating from mesenchymal tissues, compared with carcinoma of epithelial tissue origin, although uncommon, both are malignant tumors, and liposarcoma belongs to soft tissue sarcoma. Liposarcoma is a soft tissue sarcoma, which is mostly metastasized through blood line, aggressive and spreading, with advanced compression symptoms and affecting organ function. It is difficult to achieve a complete cure for liposarcoma. Liposarcoma is a tumor with a high degree of malignancy, and its treatment is difficult, often requiring a combination of various other options for treatment. Highly differentiated liposarcoma has a high rate of local recurrence after surgery. It is difficult to remove all the tumor cells by surgery, and the malignant degree of liposarcoma is higher to appear distant organ metastasis, so its metastasis rate is also higher, and the treatment of liposarcoma will also carry out radiotherapy in the local area after surgery, to reduce the local recurrence rate, and some of them have to be cooperated with chemotherapy after surgery. For highly differentiated liposarcoma, it is recommended to go to the hospital for diagnosis and treatment.