Differentiated liposarcoma is a common soft tissue sarcoma that occurs in fat-containing areas throughout the body. If the sarcoma is not severe and is treated promptly, the cure rate is usually about 80%, but if the sarcoma is more severe and in poor health, the cure rate will decrease. Differentiated liposarcoma is a highly malignant tumor that is usually large and presents as a deep, painless, gradually growing mass. Surgery can usually be used to remove the tumor, along with radiation therapy. If the patient’s symptoms are not serious and the surgery, radiotherapy and chemotherapy (Selenisol, disulfiram, eribulin, trabectedin, etc.) are timely, coupled with good health, the recovery is faster, and in most cases the cure rate can reach about 80%. However, if the disease is detected late, the condition is more serious and the recovery is poor, the cure rate will be significantly reduced. During the recovery period, we should pay attention to a light and nutritious diet, appropriate intake of high-calorie, high-protein, high-vitamin food, and avoid excessive pessimism and negativity, which can improve the cure rate.