Ultrasound performance of liposarcoma varies according to the different degrees of differentiation, such as highly differentiated liposarcoma can be a strong echogenic mass, uneven, blood flow is not rich, etc. Therefore, liposarcoma needs to consult a doctor in time and improve the examination to differentiate. Highly differentiated liposarcoma B ultrasound manifestation for blood flow is not rich, strong echogenic mass, not uniform, can also see strong echogenic separation of light band. Mucinous liposarcoma is mainly water coexisting with soft tissue, ultrasound shows low to no echo area, this type of liposarcoma is highly malignant. De-differentiated liposarcoma is mainly a parenchymal mass, containing fat, and ultrasound manifests as a multiechoic area of varying intensity, with well-defined echogenic zones, rich blood flow, and regular morphology. Liposarcoma is mostly found in adult males, preferably in soft tissues, and has the possibility of malignant transformation, therefore, once found, it should be timely medical treatment, and it can be treated in dermatology and general surgery, and most of them are mainly resected by surgery, and after surgery, it should be treated with radiotherapy and chemotherapy, and regular review.