Paratesticular dedifferentiated liposarcoma can be treated with surgical therapy, radiotherapy and chemotherapy. 1. Surgery: Surgery is the best way to treat dedifferentiated liposarcoma. Wide excision is usually used to prevent recurrence of the disease. The patient’s physical condition is usually evaluated before surgical treatment. 2. Radiotherapy: radiotherapy is the best adjuvant therapy besides surgical therapy, which can increase the local tumor control rate. 3. Chemotherapy: Cytotoxic drugs such as cyclophosphamide can be used for treatment; or antimetabolic antitumor drugs, such as fluorouracil and other drugs; hormonal antitumor drugs such as testosterone propionate can also be used to treat dedifferentiated liposarcoma. Please strictly follow the doctor’s instructions and do not take medication on your own. Deafferented liposarcoma is a subtype of liposarcoma. Deafferented liposarcoma is usually a large painless mass, and 40% of the cases of deafferented liposarcoma have a tendency of local recurrence. Therefore, it is important to go to the hospital for timely examination and treatment under the guidance of a doctor.