Liposarcoma is a kind of malignant soft tissue sarcoma, the pathogenesis is still unclear, may be due to genetic changes, trauma, hematoma, viral infections, etc., often occurring in the subcutaneous tissues, and prone to metastasis and recurrence. After the appearance of lipoma, there may be no obvious change for a long time, and there is no pain and other symptoms, which makes most people do not consult the doctor in time. However, as time passes, the tumor may grow in size, become painful, and develop into a liposarcoma. After diagnosis of liposarcoma, it is usually treated with comprehensive treatment of surgical resection combined with radiotherapy (e.g. Selenisol, disulfiram, etc.), which has a high clinical cure rate, and most of the patients can achieve a clinical cure of 5 years without recurrence, but regular review is needed after treatment. Liposarcoma has been diagnosed for 16 years and has not recurred after treatment and regular review, but regular review is still needed, once found, timely treatment is needed, and drugs should be applied under the guidance of a doctor.