Renal liposarcoma is a kind of malignant tumor, which mainly adopts the comprehensive treatment method of surgery, radiotherapy and chemotherapy. 1. Surgical treatment: radical nephrectomy is generally adopted, and if necessary, extended resection or multi-organ combined resection is feasible. 2. Radiotherapy: Radiotherapy or chemotherapy is needed after surgery if the pathological examination suggests that the tumor is low-differentiated sarcoma, the tumor size is more than 10cm, or the tumor cannot be completely resected by surgery. Radiotherapy can delay tumor growth, reduce local recurrence rate and prolong tumor-free survival. 3. Chemotherapy: Anthracyclines (e.g., doxorubicin, epirubicin) and isocyclophosphamide are the main first-line chemotherapeutic agents. Adverse effects such as nausea, vomiting and hepatotoxicity may occur with the use of chemotherapeutic agents. After renal liposarcoma, you should go to the hospital and choose the appropriate treatment under the guidance of your doctor to prevent further progression of the disease.