Generally speaking, lithotripsy and lithotripsy are not recommended for larger gallbladder stones because the treatment itself can induce more serious complications; and anti-inflammatory treatment is only indicated for those who have an acute attack of calculous cholecystitis, or whose inflammation is more than 3 days old and makes surgery more difficult. Nowadays, it is internationally recognized that surgery is the gold standard of gallbladder stone treatment. The diameter of the gallbladder duct is about 0.3 cm, the diameter of the bile duct is usually not more than 0.6 cm, and the maximum diameter allowed by the lower sphincter of the bile duct is usually not more than 0.3 cm. Very often, gallbladder stones can enter the bile duct through the duct, which can induce spasm of the lower sphincter of the bile duct. This can lead to cholangitis manifestations such as fever, abdominal pain and jaundice (Charcot’s triad) due to poor bile excretion and increased pressure in the bile duct. At the same time, poor pancreatic excretion and activation of various digestive enzymes in the pancreatic juice cause self-digestion, which leads to acute pancreatitis. It is well known that both acute cholangitis and acute pancreatitis are extremely dangerous and expensive (especially pancreatitis), and sometimes you can’t buy back your life with money. 2. Acute and chronic cholecystitis, gallbladder cancer: Due to the stimulation of stones, the wall of gallbladder can appear acute inflammation, congestion and edema, thickening, ultrasound manifests as thickening of gallbladder wall, “bilateral sign”, symptoms manifest as abdominal pain, fever, bad habits, vomiting, etc. Through anti-inflammatory treatment, the inflammation can subside and the symptoms can be relieved; however, the stones are still there, which will repeatedly stimulate and recur inflammation, followed by chronic cholecystitis. In the medical field, many chronic inflammatory diseases are pre-cancerous lesions. The gallbladder is no exception. Studies have shown that chronic cholecystitis can evolve into gallbladder cancer in the long term. Hepatobiliary and pancreatic tumors are all highly malignant, in the order of pancreatic cancer, gallbladder cancer, liver cancer, bile duct cancer and duodenal papillary cancer, respectively. It is even more malignant than liver cancer! 3, gallbladder stone impaction can also press through the gallbladder wall, bile duct wall or intestinal wall to form endoleaks, or lead to Mirizzi syndrome: so, gallbladder stone is compelled to do surgery. It is just that surgery can be elective (chosen in the non-inflammatory acute phase, which is relatively safer), and the modality can and is optional. With the advancement of technology, laparoscopic and small incision surgery with small incisions can be chosen, and there are even many people who can choose gallbladder preservation surgery without the worry of removing the gallbladder.