Health promotion in some hospitals, including some gastroenterologists, tell patients that gallbladder stones do not require surgery if they are asymptomatic. This view is questionable. In clinical practice, we have come across many patients who have had gallbladder stones for decades (most of them are women), and who have been examined for gallbladder stones without any symptoms or minor epigastric discomfort or “gastric disease” without paying attention to them, and who later present with significant pain in the upper abdomen or skin jaundice or epigastric masses and seek medical attention. Although the patients were given great surgery and post-surgical follow-up treatment, the prognosis of most of them is extremely poor. Many family members including patients regret not having their gallbladder removed earlier. Most patients with gallbladder cancer are combined with gallbladder stones, and gallbladder stones are also considered to be one of the causes of gallbladder cancer. Epidemiology in the literature reports that countries with high gallbladder resection rates have lower incidence of gallbladder cancer. Combining the literature and work experience, the following conditions can be considered for surgical removal of the gallbladder for reference only: 1. stones larger than 3 cm; 2. gallbladder-filled stones; 3. gallbladder atrophy although small but with stones inside; 4. porcelain gallbladder; 5. gallbladder stones with chronic inflammation.