Many patients come to the clinic with flesh jumping, worried and fearful, suspecting that they have motor neuron disease. So, is this really true? First of all, it is important to understand why meat jumping occurs. The involuntary muscle jumping is the result of involuntary excitation of some muscle fibers, and any disease that can cause increased excitability of some nerve fibers or muscle fibers can cause flesh jumping. It is true that motor neuron disease, due to lateral sclerosis and necrosis of anterior horn cells, leads to the loss of upstream inhibition of the terminal muscle fibers and release symptoms, causing them to contract with increased excitability, resulting in sarcoid jumping. However, motor neuron disease is often accompanied by muscle atrophy and weakness, especially in the small muscles of the hands, which gradually progress to the whole body and even to the face. This is the most characteristic symptom. In contrast, flesh throbbing is only one of the accompanying symptoms. Secondly, many physical diseases can also produce flesh throbbing. Anxiety, depression, insomnia, neurosis, fatigue syndrome and other mental factors that lead to increased neural excitability can also produce flesh jumping. And it is also extremely common. Even poor rest can also produce flesh throbbing. Therefore, there is no need to be afraid of flesh jumping. If it is indeed similar to motor neuron disease and needs differential diagnosis, EMG can be done to clarify.