Redness of the lips and mouth is the initial manifestation of oropharyngeal changes caused by cutaneous mucosal lymph node syndrome. Kawasakisyndrome is an acute systemic vasculitis that affects mainly infants and children. Despite extensive research by many scholars, the etiology of Kawasaki disease is still unclear, but numerous epidemiological and clinical observations suggest that Kawasaki disease is caused by infection, given the fever, rash, conjunctival congestion, cervical lymph node enlargement, and the prevalence in children and the apparent geographic distribution of outbreaks in this self-limiting disease suggest that its onset is related to infection. The cause of Kawasaki disease is still unknown, although many scholars have done a lot of research, but a lot of epidemiological and clinical observations show that Kawasaki disease is caused by infection, given that this self-limiting disease exhibits fever, rash, conjunctival congestion, swollen cervical lymph nodes, as well as the prevalence in children, and the obvious geographical distribution of outbreaks suggest that its onset is related to infection. The main prevention work is to prevent various viral infections, especially vaccination and other measures. In addition to isolating the source of infection and cutting off the transmission route, immunoprophylaxis is an important and effective measure, with artificial autoimmunization such as vaccination with live attenuated virus vaccines (polio vaccine, cowpox vaccine, measles vaccine, etc.) and inactivated virus vaccines (influenza vaccine, rabies vaccine, etc.).