Menopausal depression, is a common mental disorder that often occurs during menopause. Due to the decrease of estrogen secretion during menopause, a series of symptoms will appear clinically, such as irritability, agitation, insomnia, etc. Physiologically, due to the change of various functions, loss of appetite, dry mouth, palpitations, change of blood pressure, chest tightness, numbness of limbs, loss of libido, etc. The physiological changes are thought to aggravate the patient’s psychological discomfort, and often the psychological symptoms will be aggravated with the aggravation of the physiological symptoms, and after treatment After treatment, the physiological symptoms will disappear before the psychological symptoms. Menopausal depression is also one of the psychological changes that can have serious consequences for the patient and the family if the patient is depressed for a long time. Menopausal depression is often characterized by disassociation, a preference for solitude, low mood, lack of motivation, loss of interest in life and work, and even weeping, sadness and joy, and eventually patients feel self-induced pain and even suicidal tendencies. Menopausal depression is not an incurable disease, the treatment of menopausal depression as long as it includes both psychological and pharmacological treatment. It is treated medically with symptomatic supportive treatment of antidepressants and anxiety, and with estrogen replacement therapy to replenish the rapidly declining estrogen levels. In addition to the patients themselves, family members should also pay attention to understand the patients, care and help them to recover as soon as possible, do a good job of psychological adjustment, timely detection and correction of the patient’s bad mood, the patients themselves should also learn to self-regulate, not to take the bull by the horns, often see outdoor activities, more communication with family and friends to avoid extreme consequences.