Treatment of gallbladder stones should vary depending on the patient’s condition and the course of the disease. Asymptomatic gallbladder stones can generally be temporarily observed and regularly reviewed. Patients with symptomatic gallbladder stones can choose conservative treatment, surgical treatment and minimally invasive treatment under the diagnosis of a specialist. Conservative treatment 1, asymptomatic gallbladder stones can be temporarily observed In clinical practice, some patients are often found to have gallbladder stones during health checkups, but most of them may not have any symptoms, so these asymptomatic gallbladder stones can be temporarily observed, but they should be regularly reviewed by ultrasound, etc. Diet should avoid fatty foods and moderate increase of water intake, etc. Generally, treatment is not advocated. 2.Lithotripsy treatment Gallbladder stones must pass through the gallbladder duct which is only 2~3mm in diameter to leave the gallbladder and enter the common bile duct. For gallbladder stone removal treatment, the two conditions of good gallbladder contraction function and maximum stone diameter <2~3mm must be present. Therefore, before treatment, cholecystography and ultrasound must be performed and the change in gallbladder volume must be observed before and after the fatty meal to compare the size of gallbladder stones and the contractile function of the gallbladder. This treatment option was prevalent in the 1970s and 1980s and was effective in some patients. The number of stones could be reduced by lithotripsy, but evacuation was difficult. Even after evacuation, the gallbladder mucosa is damaged, the lesioned gallbladder still exists, and the lithogenic environment is not eliminated, so it is very easy to regenerate and recur. In addition, a series of complications may occur during lithotripsy treatment, such as biliary colic, acute cholecystitis, acute cholangitis, acute pancreatitis, and in serious cases, obstruction of the bile ducts, acute dilatation or even perforation of the gallbladder, obstructive jaundice, liver function impairment and purulent cholangitis in the lower part of the common bile duct, and acute necrotizing pancreatitis in the obstruction of the pancreatic ducts, all of which can be life-threatening. Therefore, lithotripsy treatment is rarely used now. 3, drug lithotripsy treatment Among the many Chinese and Western drugs, the drugs that are recognized to have dissolved gallbladder cholesterol stones are goose deoxycholic acid and ursodeoxycholic acid. The former has a large toxic side effect and is now less used, while the latter has relatively light side effect, 8~10mg/kg per day, divided into 3 times orally after meals or 1 time orally after dinner, the course of treatment is 1~2 years, the efficiency is 50~90%, if there is no obvious lithotripsy effect after 9 months of lithotripsy treatment, it is not suitable to continue taking the drug. There is still recurrence after lithotripsy, and the recurrence rate is about 10% per year. 4.Lithotripsy treatment Lithotripsy treatment of gallbladder stones is not ideal due to many factors such as anatomical structure (anatomical variation, easy folding of gallbladder tract, two narrow gaps between gallbladder duct and duodenal papilla), contraction function of gallbladder, bile properties, composition of gallstones, etc. It is also easy to cause side injury to gallbladder, liver, intestine and other surrounding organs or easy to embed in gallbladder duct and duodenal papilla after stones become small fragments. It is rarely used clinically because it may cause acute obstructive cholecystitis, cholangitis and pancreatitis after the stones become small fragments and become lodged in the gallbladder duct and duodenal papilla, leading to serious complications. Surgical treatment Cholecystectomy for gallbladder stones, cholecystitis, gallbladder polyps and other gallbladder diseases has a history of one hundred years and has proved to be a very successful, effective, safe and reliable classical treatment method. Minimally invasive treatment Minimally invasive surgery is a new surgical technique developed rapidly in the past decade or so, which is very different from the traditional surgical methods in the past. It has the characteristics of small trauma, fast recovery, safety and reliability in line with cosmetic.