”Can gallbladder develop cancer too?” Many people would have this question, as if they have never heard of the term “gallbladder cancer” before. Yes, generally speaking, the incidence of gallbladder cancer is not high, and the general public is rarely exposed to it. However, gallbladder cancer is so deadly that it can be said to be the king of cancers. Its 5-year survival rate is less than 5% and the median survival period is less than 6 months, that is to say, half of the patients suffering from gallbladder cancer will not live more than half a year, which is the power of this invisible killer that makes people feel scared and frightened. Gallbladder cancer is a malignant tumor that occurs in the mucosa of gallbladder and its main pathological type is adenocarcinoma. The ratio of male to female gallbladder cancer patients is roughly 1:3, which means that women have a higher risk of gallbladder cancer. Gallbladder cancer is rare in adolescents, but its incidence increases gradually with age, peaking after age 60. The most common causative factor of gallbladder cancer is gallbladder stones, especially larger stones and cholesterol stones. About 75% to 90% of gallbladder cancer cases have a background of gallstone disease. Does this mean that gallbladder stones are the cause of gallbladder cancer? This question is still somewhat controversial. However, having gallbladder stones and chronic cholecystitis are indeed important factors associated with the development of gallbladder cancer, in addition to intestinal fistula, S. typhi infection, and abnormal common opening of the pancreaticobiliary duct. Since gallbladder stones are obviously correlated with gallbladder cancer, is it necessary to undergo gallbladder removal surgery as soon as gallbladder stones are found? The answer is no. Because gallbladder cancer occurs in only 0.3%-3% of gallbladder stone patients, it is not necessary to perform cholecystectomy for all gallbladder stone patients to prevent gallbladder cancer. However, once you find out that you have gallbladder stones, you should not take it lightly, even if it is not painful or itchy, you should go to the relevant hospital in time to receive the guidance of professional doctors.