Mesenteric lipomatosis is a rare chronic nonspecific inflammatory reaction involving the mesenteric adipose tissue. It is not frightening if it affects the viscera to a low degree; it is more frightening if it affects the viscera to a high degree. It is not scary if the patient has only mild involvement of the mesentery, no intestinal obstruction or no severe abdominal mass, as well as no gastrointestinal bleeding, and no impact on the liver, kidneys, or other functions. If the patient does not receive timely treatment, intestinal obstruction, lymphatic obstruction with ascites, steatorrhea, and protein-losing enteropathy may occur in the later stages of the disease, and even gastrointestinal bleeding may occur, thus seriously affecting the quality of life and jeopardizing the life of the patient, which is more terrible. If the patient has mesenteric lipomatosis, it is recommended to go to the hospital in a timely manner, after a clear examination and actively cooperate with the doctor for treatment, to avoid aggravation of the condition.