Mesenteric lipomatosis is a rare chronic nonspecific inflammatory disease involving mesenteric adipose tissue, characterized by necrosis, chronic inflammation and fibrosis of mesenteric adipose tissue. It has a relatively characteristic appearance on abdominal CT. Typical CT manifestation is around the mesenteric blood vessels, clear boundaries, uneven density of single or multiple soft tissue density mass (compared with the density of retroperitoneal fat), which can be seen within the fat density and low-density cystic degeneration area, large blood vessels and mass around the “fat halo ring”, intestinal collaterals shifted to the surroundings, and so on. Glucocorticoids are usually preferred, with the dose chosen according to the severity of the disease. Immunosuppressive therapy, such as azathioprine or cyclophosphamide, is required. Glucocorticoids are usually given in adequate doses. If CT demonstrates mesenteric lipomatosis, treatment is prescribed to avoid delay.