Subcutaneous seborrheic-like non-Hodgkin’s lymphoma needs to be further evaluated for extent, staging, and treatment with chemotherapy, radiotherapy, and targeted therapy. Subcutaneous seborrheic-like non-Hodgkin’s lymphoma is a relatively rare lymphoma, and patients need to undergo a systemic evaluation, such as PET-CT, to assess the localized lesions as well as the systemic condition. If the lesions are limited, localized radiotherapy combined with chemotherapy can be used, often with good results. For more extensive lesions, radiotherapy cannot kill all the lesions, and active chemotherapy should be used. Patients with corresponding gene mutations can be treated with a combination of radiotherapy, chemotherapy, targeting or even immunotherapy to increase the probability of cure. Patients with subcutaneous lipomatous inflammatory-like non-Hodgkin’s lymphoma are advised to take comprehensive treatment under the guidance of a doctor according to the specific situation, so as not to delay the condition.