Mesenteric root lipomatitis generally has a favorable prognosis and does not affect the patient’s life expectancy. Mesenteric lipomatitis is a chronic, inflammatory disease that mainly involves the mesenteric adipose tissue, preferably in the small intestine mesentery, and is a benign disease with an unknown etiology, which may be related to decreased immunity, trauma, ischemia, infection, surgery, and so on. Mesenteric root lipomatosis involves a much smaller area of the mesentery. The common symptoms of mesenteric lipomatosis are abdominal pain, diarrhea, abdominal mass, fever, emaciation, etc. Generally, the disease has a good prognosis, and it can be relieved and recovered by itself, completely cured, and it does not affect the patient’s life expectancy and quality of life. It is a self-limiting disease, and mainly focuses on symptomatic supportive treatment, and those with severe symptoms can use drugs such as hydrocortisone to alleviate the symptoms. Therefore, patients with mesenteric root lipomatosis do not need to worry too much, daily light and easy to digest diet, appropriate exercise to help recovery, if necessary, seek medical help.