It takes about 10-20 years for mesenteric lipomatosis to develop into an advanced stage. Patients should actively cooperate with the acceptance of the doctor’s treatment, maintain good living habits and keep a good state of mind. Mesenteric lipomatitis is a chronic non-specific inflammation involving mesenteric adipose tissue, which mostly occurs in middle-aged and elderly people. The onset of spasmodic abdominal pain, accompanied by nausea, vomiting, fatigue and other symptoms, some patients will also have a large amount of fluid in the abdomen. The causes of mesenteric lipomatosis are mainly related to immunocompromise, trauma to the mesenteric adipose tissue, and subacute infections. With low immune function, it takes 10-20 years for the inflammation to develop into an advanced stage, so it takes 10-20 years for mesenteric lipomatitis to develop into an advanced stage. The treatment for mesenteric lipomatosis is mainly symptomatic. For obvious pain, antispasmodic and analgesic drugs, such as ibuprofen, are used; for digestive or immune deficiency, immune-boosting drugs, such as glucocorticoids and cyclosporine, are prescribed. If the patient has a mass in the abdomen, surgical resection is required. Mesenteric lipomatosis is usually better through clinical treatment, but if left untreated, it may develop into advanced stage in 10-20 years.