Lupus lipomatitis can generally be treated by applying glucocorticosteroids such as methylprednisolone and combined with immunosuppressants such as hydroxychloroquine, cyclophosphamide, azathioprine and other drugs. Lupus lipomatitis is a manifestation of systemic lupus erythematosus, also known as deep lupus. Lupus sebaceous meningitis is typically characterized by deep subcutaneous nodules or plaques, which are hard and mobile, usually with pressure or tenderness, and the center of the skin damage is usually depressed and accompanied by scarring. The size of the nodules varies, the margins are clear, the skin overlying the nodules may be normal, and sometimes the skin overlying the nodules may be atrophic, with dilated capillaries or typical discoid erythematous lesions, and rarely ulceration or erosion of the skin may occur. Lupus lipomatitis can be treated with glucocorticoids such as methylprednisolone tablets and immunosuppressants such as hydroxychloroquine sulfate tablets, cyclophosphamide tablets, azathioprine tablets or thalidomide tablets. Patients with lupus lipomatitis are advised to consult regular hospitals and follow the doctor’s instructions for treatment, and not to use medication on their own.