Calf soreness in diabetic patients is usually due to neuropathy of diabetic lower limbs, or diabetic lower limb arterial vasculopathy, which can be actively controlled by blood glucose, and can be orally administered with drugs that nourish the nerves (e.g., methylcobalamin, etc.), drugs to reduce nerve pain (e.g., pregabalin, etc.), and antiplatelet or circulatory-improvement drugs. There may also be other causes of calf soreness. Diabetic patients can be examined by lower extremity electromyography or by ultrasound of the arteries of both lower extremities to determine whether there is diabetic neuropathy or vascular lesions of the lower extremities. If the diagnosis of diabetic lower limb neuropathy caused by pain, patients can take oral nerve nutrient drugs (such as methylcobalamin, etc.) and drugs to reduce nerve pain (such as pregabalin, etc.). If the diagnosis of lower extremity vascular stenosis or occlusion caused by calf pain, can be oral antiplatelet or improve the circulation of drugs to improve the blood flow of the lower limbs, relieve pain, serious patients need to undergo surgical intervention. At the same time for patients with high blood sugar to actively control blood sugar, delay the emergence of complications. High blood sugar calf pain may also be caused by other reasons, it is recommended that patients with high blood sugar calf pain in time to the hospital clinic, under the guidance of the doctor to clarify the cause of the disease, targeted treatment, so as not to delay the condition.