Muscles and ligaments are the power base of various human activities, and their end devices are the bones to which the muscles are attached, and they are the power transmission hubs that drive the bones and joints, and they are also the parts where stresses are concentrated and intersected, so they are very easy to be injured. Repeated injury to the local muscle, when the injury healed can leave scars or adhesions, scar tissue can reduce the number of local blood vessels or small diameter, the occurrence of local microcirculation blood flow regulation ability to reduce the muscle blood supply and anaerobic work ability to lose. The local ischemia of the muscles causes pain due to peripheral nerve stimulation, and the patient cannot tolerate prolonged physical activity or even sedentary activities. For example, long-term incorrect posture or psychological depression can cause physiological contracture at the level of local muscle segments, long-term repeated muscle spasm causes muscle ischemia, sterile exudation, scar formation, local myofascia often undergoes postural load and extreme tension, fatigue causes postural injury, repeated exertion causes micro-tearing muscle damage, and pain-causing substances appear around the microvascular reaction zone of myofascia. Rheumatoid myositis, ankylosing spondylitis or viral myositis cause peripheral nerve compression due to muscle swelling, which may form nociceptive sensitive points or painful myocardial sclerosis for a long time and undergo a complex intertwined reaction process of long-term local irritation, inflammation, healing, hyperplasia or scarring, with painful local tissues and calcification of inflammatory exudate deposits and development of myoclonus. Hypoxia or lack of energy metabolism may be secondary to a decrease in local blood flow and is an important mechanism of painful MPS that can cause muscle dysfunction and tissue destruction, therefore any means of improving microcirculation to the muscles and nerves even local massage or walking can provide some relief from the painful symptoms of CMPS. Pathological features of painful nodules: 1. a bundle of muscle fibers in a muscle surrounded by aseptic inflammatory myofilaments that are stiffer. 2. a lesioned dermatomal nerve. 3. proliferating inflamed fatty connective tissue that is tightly attached to deep fascia. 4. a site where motor nerves enter the muscle. Painful nodules mostly occur in the supraspinous ligament, interspinous ligament, posterior laminae, supraspinous muscle group, intertransverse muscle group, occipital ring fascia, levator scapulae, trapezius, rhomboid, psoas, sacrospinous, and so on.