Patient: My wife has depression, diagnosed locally, has been on electroconvulsive therapy, currently taking regular medication, currently taking Sellett twice daily, and valproate twice daily, but the depression comes on once a month for two weeks each time, I personally studied the guidelines, but I’m at a loss, what else can I do? I have studied the guidelines, but I have no idea what to do. Jiao Yumei, Psychiatry Department, Shanghai Mental Health Center: Hello. First of all, we have to determine the diagnosis because there are biphasic and monophasic depression, as well as rapid cycling and mixed episodes, which all have depressive symptoms, but the treatment plan is not exactly the same. Therefore, a clear diagnosis is needed to determine the treatment plan. If it is convenient for you, you can come to see me in person, and my consultation time is detailed on my personal website. It is better to see my special needs clinic during the initial consultation, so that you can have more time to understand your condition. If it is not convenient for you to come to see me in person, you can also consult with me by phone through the platform, so that the communication will be more direct and effective.