Hypertonic coma: Hypertonic non-ketotic diabetic coma, referred to as hypertonic coma, is a rare and serious acute diabetic complication, whose main clinical features are severe hyperglycemia, dehydration, and elevated plasma osmolality without significant ketoacidosis. 2, sedation, anesthetic-induced coma: Patients with hypopituitarism crisis are very sensitive to sedation and anesthetics, and the amount of thorns commonly used can cause patients to fall into a long period of sleep or coma. 3, CNS depressants induced coma: CNS depressants induced coma is one of the types of pituitary crisis and pituitary stroke crisis, that is, when the anterior pituitary gland is hypopituitary, adrenocorticotropic hormone and thyroid hormone deficiency, the body’s stress capacity is reduced, in the case of infection, vomiting, diarrhea, dehydration, cold, hunger, and the application of sleeping pills or anesthetics and induced crisis. Acute neuroendocrine lesions caused by sudden intra-tumoral hemorrhage, infarction and necrosis of pituitary tumors, resulting in expansion of the tumor, are called pituitary strokes. 4.Proximal coma: Hepatic encephalopathy (hepatoencephalopathy) used to be called hepatic coma, which is a syndrome of central nervous system dysfunction caused by severe liver disease and based on metabolic disorders, and is one of the manifestations of severe hepatocellular failure. The main symptoms are impaired consciousness, behavioral disorders and coma, while subclinical or occult hepatic encephalopathy has no obvious clinical manifestations or biochemical abnormalities and can only be diagnosed with refined mental tests and/or electrophysiological tests. Portal shunt encephalopathy is the most common, and the main mechanism of occurrence is portal hypertension, with collateral circulation between the portal vein and the vena cava, resulting in a large amount of portal blood bypassing the liver and circulating in the body. 5, deep coma: deep coma, total loss of consciousness, no response to external stimuli, various reflexes disappeared, generalized muscle relaxation. Patients in deep coma, the clinical manifestations are no response to any stimulus, no spontaneous activity, body muscle relaxation, eye fixation, pupil dilatation, various reflexes disappeared, and obvious changes in vital signs, such as irregular breathing, heart rhythm disorders, blood pressure fluctuations, etc.