The causes of calf pain when sleeping up are strenuous exercise, lumbar disc herniation, varicose veins, hypocalcemia and so on. 1. After strenuous and repeated exercise: strenuous exercise or excessive exercise, such as running, frog jumping, deep squatting, etc., can lead to excessive production of lactic acid in the body, lactic acid can not be metabolized in a timely manner and build up in the body, the next day can be caused by muscle aches and pains. 2. Herniated lumbar intervertebral discs: When people with herniated lumbar intervertebral discs sleep, the protruding nucleus pulposus or intervertebral discs may press on the local nerve roots because of bending movements, which may cause lumbar and leg pains, numbness and other abnormal sensations. 3. Varicose veins: Varicose veins and impaired venous return in the lower limbs can also cause pain in the calves and feet. 4. Hypocalcemia: hypoparathyroidism, intestinal malabsorption and other factors lead to low blood calcium, which can cause twitching of the hands and feet, muscle spasms, and may also have symptoms of calf pain. Sleeping up calf pain may also have other pathological factors, if the symptoms are not relieved, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.