Dysmenorrhea is a common symptom for women. Some women have severe dysmenorrhea, which seriously affects their quality of life. The most common clinical treatment for dysmenorrhea at present is oral pain medication. There are many pain medications on the market today for menstrual cramps. There is no significant difference in the response of most patients to each medication. Pain medications are generally effective in the treatment of dysmenorrhea. Therefore, patients can choose any pain medication for dysmenorrhea each time they choose a medication. However, individual patients are not very sensitive to a particular drug. Therefore, it is recommended to choose another medication when this occurs. It should be noted that pain medication for menstrual cramps cannot achieve complete absence of menstrual cramps symptoms, but only alleviate the level of pain and reduce the patient’s suffering. In addition, patients can also choose herbal medicine to regulate the symptoms of dysmenorrhea. As for stubbornly aggravated dysmenorrhea, patients are advised to consult a local hospital to exclude the possibility of organic uterine lesions, if the uterus has organic lesions, then oral painkillers alone are not effective. In conclusion, there is no significant difference in the effectiveness of oral painkillers in the treatment of dysmenorrhea.