The etiology of ankylosing spondylitis is more complex and there is no exact cause. Studies have found that ankylosing spondylitis is significantly associated with human genetic factors, environmental factors, infections, etc. In particular, it has been confirmed that there is a significant correlation with the human leukocyte antigen HLA-B27 gene, which has a positive rate of 2%-7% in healthy people with ankylosing spondylitis, while in patients with The rate of positivity of the gene can be as high as 90% in patients with ankylosing spondylitis. Ankylosing spondylitis is a chronic inflammatory disease significantly associated with the human leukocyte antigen B27 gene, mainly involving the sacroiliac joints, spinal prominences, paraspinal soft tissues and peripheral joints of the spine. Patients with advanced ankylosing spondylitis may develop ankylosis of the spine or peripheral joints, and they may experience severe physical dysfunction. There are three main types of treatment for ankylosing spondylitis: 1. nonsteroidal pain medications, mainly Fotarolim extended-release tablets. 2, drugs to control the condition. 3, For the treatment of ankylosing spondylitis, the most effective drugs are biological agents. In addition, if spinal deformities occur, surgical correction can be performed in spine surgery.