The presence of gallbladder stones can frequently irritate the gallbladder mucosa and lead to the development of cholecystitis. Long-term inflammatory irritation can affect the functions of the gallbladder such as contraction, and in a few cases, cancer – gallbladder cancer – may occur. If a stone blocks the outlet of the gallbladder, it can cause epigastric cramps, nausea and vomiting; if the stone is lodged in the abdomen or neck of the gallbladder, it can cause enlargement of the gallbladder, increased abdominal pain, fever or nausea and vomiting, and other gastrointestinal symptoms, or even gallbladder perforation and peritonitis. In addition, the stone may also drain into the bile duct, which can cause bile duct obstruction. The pain may be mild, but the severe abdominal pain, jaundice, chills and fever, and even shock and psychiatric symptoms can be life-threatening if not rescued in time. Doctor’s tip: Stones may also drain into the bile ducts and can cause bile duct obstruction. This can lead to pain, severe abdominal pain, jaundice, chills and fever, and even shock and psychiatric symptoms, which can be life-threatening if not resuscitated in time. It is important to note that 80-90% of pancreatitis is caused by biliary inflammation or stones. A small percentage of these pancreatitis presents with a vicious clinical severity, and the patient quickly develops shock, peritonitis, etc. The clinical course is dangerous, the management is tricky and the mortality rate is high. Even if they survive, the rate of sequelae is very high and can affect life and work.