Symptoms of multiple myeloma peripheral neuropathy commonly include asymmetric motor, sensory neuropathy and autonomic neuropathy. 1. Motor neuropathy: when severe peripheral sensory neuropathy occurs, most of them involve the motor nerves, further muscle spasm, tremor or distal muscle weakness occurs. 2. Sensory neuropathy: peripheral neuropathy associated with multiple myeloma disease mainly manifests as distal asymmetric sensory neuropathy, such as sensory abnormalities at the ends of the limbs, numbness of the limbs, and burning sensation, etc. Generally speaking, these symptoms are relatively mild, but there is also the possibility of disability. If nerve root compression occurs, radicular pain of varying degrees can occur. In the treatment of its associated peripheral neuropathy, most of the lesions manifest in the distal extremities, with the earliest symptoms appearing in the feet, spreading from distal to proximal and manifesting glove- and stocking-like distributions and painful dullness of sensation. 3. Autonomic neuropathy: autonomic nerves are also called vegetative nerves, and there are autonomic nerves in all organs of the body, whose lesions are mainly manifested in thermoregulation and abnormal sweating; digestive system symptoms such as intestinal obstruction, constipation, etc.; genitourinary system symptoms such as urinary retention, urinary disorders, etc.; cardiovascular system symptoms such as fainting, upright hypotension, etc.. If any of the above symptoms such as muscle weakness, abnormal sensation, painful dullness, etc. occur, it is recommended to consult a doctor in time to clarify the cause of the disease with the help of the doctor and carry out targeted treatment or therapy.