The spleen is usually not palpable in the abdomen under normal conditions, and is considered enlarged if the edge of the spleen can be felt in the supine or lateral position. In megalosplenomegaly, the spleen is significantly larger, usually tens to hundreds of times larger than normal. Especially in portal hypertension, the blood flow to the spleen is obstructed, the splenic sinuses are open, the spleen is stagnant, and a large amount of blood is stored in the enlarged spleen, sometimes up to several thousand milliliters. Enlarged spleen volume is the main manifestation of spleen disease. Examination methods: 1. MRI examination of liver, gallbladder, pancreas and spleen: It can clarify the extent and scope of lesions and their characteristics, and can be differentiated from other tumors. It can confirm the diagnosis of liver, spleen cysts and cavernous hemangioma. MRI examination takes a long time, and the patient is in a dark and noisy environment. Be prepared, don’t be impatient, don’t be afraid, and keep your body position still under the guidance of the physician. Be patient and cooperate. Before the examination, provide the doctor with all medical history, examination information and all X-rays, CT films, etc. 2.Spleen imaging: It is to determine the location, size and morphology of the spleen and make a diagnosis of the lesion if necessary. Often 99mTC heat-denatured red blood cells, 113In-heat-denatured red blood cells or 51Cr-heat-denatured red blood cells are used. The purpose of splenic imaging is to determine the diagnosis of spleen location, size, nature of splenic mass and lesions, and the presence of parasplenomegaly. 3.Serological antigen antibody test: lymph node aspiration or biopsy, spleen aspiration or biopsy, routine ascites examination, etc. The above laboratory tests can be selected according to the medical history and physical examination, after making a preliminary diagnosis, and the basis of definite diagnosis can often be found for certain diseases.