In the summer of 2014, an ice bucket challenge brought a rare disease into the limelight – acromegaly. This is a very “scary” disease, many people on the Internet constantly search for information about it, the more you look at the more scared, the more scared the more carefully you look at yourself, many people even appear out of nowhere muscle tremors, a comparison of the description of the disease found that “flesh jumping” is The more you look at it, the more scared you are, the more carefully you look at yourself. Many people even have muscle tremors out of nowhere, and when you compare the description of the disease, you find that “flesh jumping” is a common symptom of motor neuron disease, so you can’t help but feel more nervous, and then you feel more and more general weakness and lack of appetite, and even weight loss and wasting, and patients often think that this wasting is due to muscle atrophy. The diagnosis of ALS requires a comprehensive medical history (especially the onset and progression of the disease), specialized neurological examination, necessary ancillary tests, and the experience of the doctor to exclude other diseases. Although no single test can confirm the diagnosis, electromyography is still crucial for localizing the diagnosis and differential diagnosis, and can be considered the most important objective ancillary test. The presence of symptoms alone without accompanying corresponding physical examination abnormalities and EMG changes can exclude motor neuron disease. Among the patients consulted on the website, there are many examples of such patients, who do not have “acromegaly”, but have the constant fear of “anaphylaxis”. The acromegaly “stone” also has such an experience, and many people keep consulting with him, and this “acromegaly” is from the name of the stone. What is “cryophobia”? This is a kind of hypochondria. Patients with this disease often have a persistent preoccupation with the fear or conviction that they have motor neuron disease. The patient’s attention or thoughts are often overly focused on his or her own health, and he or she is overly worried about his or her own health, fearing that he or she will develop motor neuron disease or is convinced that he or she is already suffering from acromegaly, and is very worried about this. Although the patient complains of many physical symptoms, after repeated visits to the doctor and repeated examinations, the patient has repeatedly been examined by the doctor and the doctor, the patient has repeatedly been examined by the doctor and the doctor, the patient has repeatedly been examined by the doctor and the doctor, the patient has repeatedly been examined by the doctor and the doctor, the patient has repeatedly been examined by the doctor and the doctor, the patient has repeatedly been examined by the doctor and the doctor, the patient has repeatedly been examined by the doctor and the doctor, the patient has repeatedly been examined by the doctor and the doctor, the patient has repeatedly been examined by the doctor and the doctor, the patient has repeatedly been examined by the doctor and the doctor, the patient has repeatedly been examined by the doctor and the doctor. In 2007, for example, the lowest admission rate of Tsinghua University in China was in Henan province, which was still at 0.015133464641740%, or about 15 per 100,000, while the highest admission rate was in Beijing, which was as high as 394 per 100,000), so there are not that many people in the general population who are unfortunate enough to suffer from motor neuron disease. Let’s look at the three symptoms most often mentioned by patients: jumping flesh, weakness, and muscle atrophy. Often patients with motor neuron disease are accompanied by flesh jumping. However, flesh jumping is not a symptom specific to neuron disease. There are many reasons for flesh jumping, some of them are pathological and some are physiological, such as after strenuous exercise, after taking some medications, or some psychological factors such as stress and anxiety. Flesh jumping alone cannot diagnose ALS, except that flesh jumping must be accompanied by evidence of muscle atrophy weakness and upper motor neuron damage. Most people may experience “flesh jumps” throughout their lives, such as involuntary eyelid fluttering, which can be improved by relaxation, stress relief, and distraction, and can be examined in a hospital when they are widespread and persistent. To elaborate with an inappropriate mathematical term: motor neuron disease is a sufficient non-essential condition for flesh throbbing. Muscle weakness in motor neuron disease often begins with small hand movements, such as writing and twisting keys and tying shoelace buttons, that are not dexterous or cannot be completed. Some patients also start with weakness in the lower extremities, which is manifested by unstable legs and easy falling, that is, the same external force acts, but before it was fine or others were fine but they would fall down. This is not the same concept as weakness and lazy speech. Some people say I just have muscle weakness, I can’t walk a short distance, I have no energy to go upstairs, I’m tired of working, and I don’t want to move, but these are just some subjective symptoms. Experienced doctors can accurately determine whether the patient really has weakness, but of course there are some more objective tests to help determine this. Finally, we must also talk about muscle atrophy, first of all, we must know that muscle atrophy and “thin” is not a concept at all, “thin” is the reduction of subcutaneous fat, but the muscle is still full, while the atrophy of the muscle must be accompanied by a decline in muscle function, that is The original movement done by this muscle can not be completed. For example, some patients say, “Look, doctor, my arms are thin, but when you arm wrestle with them, you can still see the bulging muscles and strong strength, this is not muscle atrophy. So who is prone to “cryophobia”? This part of the patient often has a personal tendency to suspicion, such as patients have worries and fears about health and life, since childhood weakness and disease, congenital deficiencies, acquired disorders, but “deficiency is not tonic”, and this belief is deep-rooted; and some patients pay too much attention to the various sensations from the internal organs and body, often produce abnormal sensations Some patients are very sensitive to changes in lifestyle and climate change, and are prone to “discomfort”; others experience similar symptoms when they hear or see others suffering from illness, and are often overly worried and afraid when they are ill. The symptoms are often more severe and persistent than others, and the treatment is characterized by poor compliance, and the medication is either highly side-effective or easily drug-resistant, making treatment difficult and ineffective. Finally, the “fear of freezing” and what should be done? As the saying goes, heart disease also needs heart medicine, patients should still adjust their personal mindset, actively into the work life, do not be too and even freakishly concerned about the changes in the body. For patients who are too anxious, they may still need some anti-anxiety medication.