After the formation of liver fibers, in the early stage of collagen fiber formation, can be dissolved by water or weak acid, so it is called soluble collagen. Long-term deposition of thick collagen fibers is not easily degraded, so it is called insoluble collagen. Therefore, the recovery of liver fibrosis in the late stage is not easy, but it can still be cut off by some proteases in the body, open its helical structure, and then degraded by some other collagenase, there are remaining fragments are also phagocytosed by the wither cells and endothelial cells and degraded within the cell. Moreover, the process of fibrosis results from the interaction between synthesis and degradation of collagen fibers in the body. When the former is hyperactive and the latter is inhibited, the fibrotic process occurs, and conversely, fibrosis can subside. Therefore, it can be said that fibrosis can be reversed to a certain extent, but if the cause of fibrosis has not been removed, or has progressed to cirrhosis, then the reversal of fibrosis is very difficult. A large number of experimental and clinical studies have also confirmed this.