Soreness in the calves may be related to liver disease, but there is no necessary connection. 1. If the patient has soreness of calf muscles accompanied by nausea and vomiting symptoms, it may be caused by hepatitis, because all types of hepatitis may induce digestive symptoms, such as abdominal pain, abdominal distension, nausea, vomiting, loss of appetite, etc. Meanwhile, due to the decline in the detoxification function of liver, it is easy to cause excessive lactic acid in the muscles, which in turn leads to muscle soreness. 2. There are many other reasons that lead to patients’ calf pain, such as cold, exertion, strain, strains, trauma, etc.. If the patient’s symptoms are serious, or continue to fail to improve, it is recommended to go to a regular hospital in time, after clarifying the cause of the disease, targeted treatment under the guidance of the doctor, in order to reduce the adverse effects of the disease.