Heel pain together with calf pain may be caused by physiological factors, but also may be a symptom of certain diseases, such as lower limb vascular neuropathy, lumbar spine lesions, local presence of malignant tumors, infection, tuberculosis, etc.. 1. Physiological factors: it may be localized cold, overwork or trauma: cold or overwork can lead to local inflammatory reaction from the calf to the heel, causing inflammatory irritation pain. 2. Pathologic factors (1) Lower extremity vascular neuropathy: such as varicose veins, venous thrombosis, arterial embolism or peripheral nerve inflammation, diabetes mellitus, etc., can also cause heel pain along with the symptoms of calf pain, usually associated with ischemia, neuroinflammatory response. (2) Lumbar spine lesions: such as pyriformis syndrome, lumbar disc herniation, lumbar spinal stenosis, lumbar spondylolisthesis and other diseases stimulate the compression of the nerves, which can cause heel pain symptoms. (3) local presence of malignant tumors, infection, tuberculosis: such diseases can also cause calf to heel pain, while the patient may be accompanied by emaciation, fatigue and other systemic clinical manifestations. When the symptoms of heel pain with calf soreness appear, you should consult a doctor in time.