The soreness of the calves the day after drinking wine may be caused by the following reasons: 1. It may be caused by some unintentional damage to the calf area. After drinking alcohol, the human body tends to have some euphoric feelings, in fact, it is possible to do some activities of greater scope and magnitude. If the calf area is caused, there is some inadvertent trauma, then it is possible to have calf area soreness the next day. 2, this situation may be caused by the calf cold, after the person drinking alcohol may cause a very hot feeling, and then the calf area clothing removed. This may cause the calf area to be cold, which then leads to muscle spasm, and the next day may feel the calf area soreness. 3, this situation may be due to some bad posture caused by. After drinking alcohol, you tend to do some bad posture, such as possibly tiptoeing your heels up for a long time. This may cause excessive muscle tension in the calf area, and then feel soreness the next day. 4, this condition may also be caused by long-term pressure. For example, if the patient is drunk after excessive alcohol consumption, the limb may be passively placed somewhere. If the calf area is under prolonged pressure at this time, it will cause ischemia and some sterile inflammation here, followed by soreness and pain the next day.