The term perimenopause has now been replaced by peri-menopause, which refers to the symptoms associated with the onset of menopause from near menopause to one year after the last menstrual period, for varying durations. The most common symptom is the appearance of irregular menstruation, associated with persistent non-ovulation, manifested by prolonged menstrual cycles, prolonged periods, increased menstrual flow, and a tendency to recurrent dysfunctional uterine bleeding. As the endometrium continues to proliferate, endometrial lesions are likely to occur, sometimes necessitating repeated scrapings to achieve hemostasis, causing great distress to the patient. The characteristic symptoms of menopause are hot flashes and sweating. Most of them are also accompanied by irritability, depression, insomnia, recurrent vaginitis and urinary tract infections. The incidence of hypertension and coronary heart disease increases significantly due to the decrease in estrogen levels. It is important to pay attention to calcium supplementation after entering menopause to prevent the occurrence of osteoporosis.