This phenomenon is caused by the beginning of ovarian failure. Due to the failure of ovarian function, women’s estrogen levels fluctuate greatly, and at the time of menopause, estrogen levels will drop rapidly. Due to the decrease in estrogen levels, women will experience neuropsychiatric symptoms, often manifesting as sleeplessness, depression, anxiety, easy agitation and memory loss. Estrogen can be supplemented appropriately, but since estrogen medications are prescription drugs, they must be taken only under the guidance of a doctor, and the dose taken varies greatly among individuals.